Competitive Inhibition of Dibasic Amino Acid Transport in Rat Kidney
نویسندگان
چکیده
منابع مشابه
Competitive inhibition of dibasic amino acid transport in rat kidney.
It has long been postulated that the dibasic amino acids, lysine, arginine, ornithine, and cystine, share a common renal tubular transport mechanism. This hypothesis has developed from two separate but related lines of evidence. The canine and human renal clearance studies of Pitts, Webber, and Brown (1, 2), Wright et al. (3), Beyer et al. (4), Kamin and Handler (5), and Robson and Rose (6) all...
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We have recently cloned, sequenced, and characterized a rat kidney cDNA (D2) that stimulates cystine as well as dibasic and neutral amino acid transport. In order to evaluate the role of this protein in human inherited diseases such as cystinuria, we have isolated a human D2 clone (D2H) by low stringency screening of a human kidney cDNA library using the radiolabeled D2 insert as a probe. The D...
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The clinical manifestations of cystinuria are localized to the urinary tract and result from the formation of cystine calculi. The findings of increased excretion of cystine, lysine, arginine, and ornithine in the urine at a time when the plasma levels of these amino acids were normal or low suggested to Dent and Rose (2) that a renal tu-1)ular reabsorptive site, shared by the involved amino ac...
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In an earlier paper from this laboratory (1) there were described the characteristics of competitive inhibition resulting from the interference of certain aromatic compounds with the association of flavin adenine dinucleotide and the separated protein of n-amino acid oxidase. Included among the inhibitors were auramine, quinine, and various other quinolines and anilines. We now present our find...
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1. More than one mode of transport can be observed for concentrative uptake of a-aminoisobutyric acid (AIB) by rat kidney cortex slices when the initial concentration of AIB in the medium is varied between 0.2 and 16 mM. 2. The relative contribution from both systems to the total observed uptake at various concentrations of AIB was calculated. The K, values for the two systems were 3.87 rnM and...
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ژورنال
عنوان ژورنال: Journal of Biological Chemistry
سال: 1962
ISSN: 0021-9258
DOI: 10.1016/s0021-9258(19)63430-7